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Development of a distributed, fully automated, bidirectional telemetry system for amperometric microsensor and biosensor applications

Rocchitta, Gaia Giovanna Maria and Migheli, Rossana and Dedola, Sonia and Calia, Giammario and Desole, Maria Speranza and Miele, Egidio and Lowry, John P. and O'Neill, Robert D. and Serra, Pier Andrea (2007) Development of a distributed, fully automated, bidirectional telemetry system for amperometric microsensor and biosensor applications. Sensors and Actuators. B: Chemical, Vol. 126 (2), p. 700-709. ISSN 0925-4005. Article.

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DOI: 10.1016/j.snb.2007.04.019

Abstract

A new bidirectional telemetry system for amperometric sensor applications has been developed. A fully automated peripheral unit (PU), constituted by a potentiostat, a two-channel I/V converter, a microcontroller unit (MCU) and a signal transmitter, was designed, constructed, and tested. A peripheral interface controller (PIC) MCU drives a digital-to-analog converter (DAC), which polarized the sensor, while the resulting anodic current is converted to a digital value by an analog-to-digital converter (ADC). The PIC firmware is developed in assembly and transferred to the MCU through a bootloader algorithm. The digital data are sent to a personal computer using a 4-byte packet protocol by means of a miniaturized 433 MHz frequency modulation (FM) transceiver with a linear range up to 200 m. The central unit (CU) is connected to a PC via Universal Serial Bus (USB). Custom developed software, implemented in Basic and C, allows the PC to control several PUs and record, plot and handle received data. The development and operation of the hardware and software are described. The system performance was evaluated using an automated dummy cell connected to the PU. The amperometric response of nitric oxide (NO), dopamine (DA) microsensors and a glucose biosensor was determined in vitro. This apparatus serves as a basic model to realize an in vivo bidirectional telemetry system built with standard components readily available at low cost.

Item Type:Article
ID Code:624
Status:Published
Refereed:Yes
Uncontrolled Keywords:Potentiostat, amperometry, microcontroller, microsensor, biosensor, biotelemetry
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Elsevier
ISSN:0925-4005
Deposited On:18 Aug 2009 10:02

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