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MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus

Cossu, Andrea and Rosu, Valentina and Paccagnini, Daniela and Cossu, Davide and Pacifico, Adolfo and Sechi, Leonardo Antonio (2011) MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus. Clinical Immunology, Vol. 141 (1), p. 49-57. ISSN 1521-6616. eISSN 1521-7035. Article.

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DOI: 10.1016/j.clim.2011.05.002

Abstract

Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection.

Item Type:Article
ID Code:6222
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacterium avium subsp. paratuberculosis, autoimmune diseases, type I Diabetes mellitus (T1DM), recombinant proteins, seroactivity
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Academic Press / Elsevier
ISSN:1521-6616
eISSN:1521-7035
Copyright Holders:© 2011 Elsevier Inc.
Deposited On:06 Jul 2011 13:20

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