Sirca, Donatella and Enrico, Paolo and Mereu, Maddalena and Peana, Alessandra Tiziana and Diana, Marco (2011) L-cysteine prevents ethanol-induced stimulation of mesolimbic dopamine transmission. Alcoholism: Clinical and Experimental Research, Vol. 35 (5), p. 862-869. ISSN 0145-6008. eISSN 1530-0277. Article.
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Background: Acetaldehyde (ACD), the first metabolite of ethanol (EtOH) appears to be involved in many of the psychoactive effects of its parent compound, including EtOH-induced activation of the mesolimbic dopamine (DA) system, thereby suggesting that ACD may participate in EtOH motivational properties. l-cysteine (Lcys), a thiol compound sequestering ACD, is able to prevent the behavioral effect of EtOH and ACD. Here we show that the stimulatory effect of both EtOH and ACD on the mesolimbic DA system is prevented by Lcys pretreatment.
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