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Plasma asymmetric dimethylarginine (ADMA) levels and atherosclerotic disease in ankylosing spondylitis: a cross-sectional study

Erre, Gian Luca and Sanna, Pietro and Zinellu, Angelo and Ponchietti, Alessandra and Fenu, Patrizia Margherita Maria Rita and Sotgia, Salvatore and Carru, Ciriaco and Ganau, Antonello and Passiu, Giuseppe (2011) Plasma asymmetric dimethylarginine (ADMA) levels and atherosclerotic disease in ankylosing spondylitis: a cross-sectional study. Clinical Rheumatology, Vol. 30 (1), p. 21-27. ISSN 0770-3198. eISSN 1434-9949. Article.

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DOI: 10.1007/s10067-010-1589-x

Abstract

Conclusive data about the prevalence of endothelial dysfunction and atherosclerotic process in ankylosing spondylitis (AS) patients with respect to the general population are lacking. Elevated plasma levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, have been reported in clinical conditions associated with endothelial dysfunction and atherosclerotic disease. We performed a cross-sectional study to evaluate plasma ADMA levels and atherosclerotic disease in AS patients. Seventeen consecutive AS patients free of any cardiovascular disease and 17 healthy controls [strictly matched for sex, age (±5 years) and atherosclerotic risk factors] were recruited. Plasma ADMA levels were assessed by capillary electrophoresis. Common carotid artery intima–media thickness (CCA-IMT), flow-mediated dilatation (FMD) and arterial stiffness (aS) were registered as surrogate markers of atherosclerotic disease. Plasma ADMA levels appeared significantly (p=0.001) higher in AS patients (0.65 ± 0.10 μmoli/L) than in the control subjects (0.54 ± 0.07 μmoli/L) while no statistically significant differences between AS and controls were demonstrated in CCA-IMT, FMD, and aS. AS patients showed increased plasma ADMA levels with respect to control subjects. On the contrary, we were not able to document a significant difference in atherosclerotic process between patients and controls.

Item Type:Article
ID Code:6168
Status:Published
Refereed:Yes
Uncontrolled Keywords:Ankylosing spondylitis, arterial stiffness, asymmetric dimethylarginine, atherosclerosis, endothelial dysfunction
Subjects:Area 06 - Scienze mediche > MED/11 Malattie dell'apparato cardiovascolare
Area 06 - Scienze mediche > MED/16 Reumatologia
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Patologia speciale medica e metodologia clinica
Publisher:Springer London
ISSN:0770-3198
eISSN:1434-9949
Deposited On:20 Jun 2011 16:52

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