UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Melatonin inhibits rat medial vestibular nucleus neuron activity in vitro

Podda, Maria Vittoria and Deriu, Franca and Giaconi, Elena and Milia, Marcella and Tolu, Eusebio (2003) Melatonin inhibits rat medial vestibular nucleus neuron activity in vitro. Neuroscience Letters, Vol. 341 (3), p. 209-212. ISSN 0304-3940. Article.

Full text not available from this repository.

DOI: 10.1016/S0304-3940(03)00209-X

Abstract

The present study evaluated the effects of melatonin on the discharge rate of tonically active medial vestibular nucleus (MVN) neurons in an in vitro slice preparation of the rat dorsal brainstem. The results demonstrated that, when melatonin was applied to the slice for a period of 7–10 min, a decrease in MVN neuron firing rate was observed in 21/58 (36%) of the cells sampled. The inhibitory effects of melatonin were present in synaptic uncoupling condition and were mimicked by 2-iodomelatonin, a non-selective agonist with high affinity for melatonin membrane receptor subtypes (MT1, MT2, MT3). The MT2 receptor antagonists luzindole and 4-phenyl-2-propionamidotetraline and the MT3 receptor antagonist prazosin did not, however, antagonise the inhibitory effects of melatonin, indicating that melatonin may act on MVN neurons through an MT1 receptor-mediated mechanism.

Item Type:Article
ID Code:614
Status:Published
Refereed:Yes
Uncontrolled Keywords:Medial vestibular nucleus, melatonin, luzindole, 4-phenyl-2-propionamidotetraline, prazosin, in vitro, rat
Subjects:Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Elsevier Science Ireland
ISSN:0304-3940
Additional Information:Pubblicato online il 27 marzo 2003.
Deposited On:18 Aug 2009 10:02

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page