Guerini, Franca R. and Bolognesi, Elisabetta and Chiappedi, Matteo and Manca, Salvatorica and Ghezzo, Alessandro and Agliardi, Cristina and Sotgiu, Stefano and Usai, Sonia and Matteoli, Michela and Clerici, Mario Salvatore (2011) SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders. Pharmacological Research, Vol. 64 (3), p. 283-288. eISSN 1096-1186. Article.
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Synaptosomal-associated protein of 25 kD (SNAP-25), a protein participating in the regulation of synaptic vesicle exocytosis and in calcium homeostasis, was recently involved in neuropsychiatric conditions. Because alterations affecting the homeostasis of calcium are described in patients affected by autism spectrum disorders (ASD) we investigated a possible involvement of SNAP-25 in ASD by evaluating five SNAP-25 gene polymorphisms in a cohort of 67 ASD children.
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