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Human chitotriosidase helps Plasmodium falciparum in the Anopheles midgut

Di Luca, Marco and Romi, Roberto and Severini, Francesco and Toma, Lucio and Musumeci, Marco and Fausto, Anna Maria and Mazzini, Massimo and Gambellini, Gabriella and Musumeci, Salvatore (2006) Human chitotriosidase helps Plasmodium falciparum in the Anopheles midgut. Journal of Vector Borne Diseases, Vol. 43 (3), p. 144-146. ISSN 0972-9062. Article.

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Abstract

High levels of plasma chitotriosidase (Chit) represents a marker of macrophage activation in human malaria infection. Plasmodium falciparum during its maturation cycle in the Anopheles midgut produces an analogue of Chit for the digestion of peritrophic matrix (PM). Our results confirm the hypothesis that Chit contained in blood of malaria patients could help P. falciparum to complete its cycle in the Anopheles midgut and to produce a bigger number of oocysts/sporozoites. This could balance the different genetic protection in humans conferred by the heterozygous Hb beta (S) gene, which seems to be associated with an increasing effect on P. falciparum transmission from humans to mosquitoes.

Item Type:Article
ID Code:609
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chitotriosidase, peritrophic matrix, malaria, Plasmodium falciparum
Subjects:Area 06 - Scienze mediche > MED/38 Pediatria generale e specialistica
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di genetica delle popolazioni, Alghero
Publisher:Indian Council of Medical Research
ISSN:0972-9062
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:18 Aug 2009 10:02

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