Di Luca, Marco and Romi, Roberto and Severini, Francesco and Toma, Lucio and Musumeci, Marco and Fausto, Anna Maria and Mazzini, Massimo and Gambellini, Gabriella and Musumeci, Salvatore (2006) Human chitotriosidase helps Plasmodium falciparum in the Anopheles midgut. Journal of Vector Borne Diseases, Vol. 43 (3), p. 144-146. ISSN 0972-9062. Article.
High levels of plasma chitotriosidase (Chit) represents a marker of macrophage activation in human malaria infection. Plasmodium falciparum during its maturation cycle in the Anopheles midgut produces an analogue of Chit for the digestion of peritrophic matrix (PM). Our results confirm the hypothesis that Chit contained in blood of malaria patients could help P. falciparum to complete its cycle in the Anopheles midgut and to produce a bigger number of oocysts/sporozoites. This could balance the different genetic protection in humans conferred by the heterozygous Hb beta (S) gene, which seems to be associated with an increasing effect on P. falciparum transmission from humans to mosquitoes.
I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore
Repository Staff Only: item control page