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Multiple sclerosis: peripheral mononuclear cells inhibit Plasmodium falciparum growth and are activated by parasite antigens

Sotgiu, Stefano and Fois, Maria Laura and Arru, Giannina and Sanna, Alessandra and Sannella, Anna Rosa and Severini, Carlo and Musumeci, Salvatore (2006) Multiple sclerosis: peripheral mononuclear cells inhibit Plasmodium falciparum growth and are activated by parasite antigens. Journal of Vector Borne Diseases, Vol. 43 (3), p. 130-132. ISSN 0972-9062. Article.

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The human genome has been subjected to selective pressures to resist to infectious agents in spite of a heavy segregational load. With this regard, thalassaemia and glucose-6-phosphate dehydrogenase deficiency have been considered an efficient genetic protection against P. falciparum malaria in Sardinia, insular Italy. In this island, some multiple sclerosis (MS)-associated HLA haplotypes have the highest odds ratios in the same highestrate malarious areas of the island. Moreover, tumor necrosis factor (TNF) polymorphisms epidemiologically associated with both MS and malaria are ten-fold more frequent amongst Sardinians compared to other populations worldwide4. A possible association between MS and malaria in this island was never analysed experimentally. We studied the immunological response of mononuclear cells to P. falciparum and the killing effect of macrophages on parasites in Sardinian MS patients and in matched healthy controls (HC).

Item Type:Article
ID Code:605
Uncontrolled Keywords:Malaria, multiple sclerosis, P. falciparum, Sardinia
Subjects:Area 06 - Scienze mediche > MED/38 Pediatria generale e specialistica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Clinica neurologica
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di genetica delle popolazioni, Alghero
Publisher:Indian Council of Medical Research
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:18 Aug 2009 10:02

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