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Pyridazine N-oxides. III Synthesis and in vitro antimicrobial properties of N-oxide derivatives based on tricyclic indeno[2,1-c]pyridazine and benzo[f]cinnoline systems

Gavini, Elisabetta and Juliano, Claudia Clelia Assunta and Mulè, Antonio Calogero and Pirisino, Gerolamo Antonio and Murineddu, Gabriele and Pinna, Gérard Aimé (2000) Pyridazine N-oxides. III Synthesis and in vitro antimicrobial properties of N-oxide derivatives based on tricyclic indeno[2,1-c]pyridazine and benzo[f]cinnoline systems. Archiv der Pharmazie, Vol. 333 (10), p. 341-346. eISSN 1521-4184. Article.

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DOI: 10.1002/1521-4184(200010)333:10<341::AID-ARDP341>3.0.CO;2-U

Abstract

A number of 9H-indeno[2,1-c]pyridazine N-oxides (3a - c) and benzo[f]cinnoline N-oxides (4,5a - c) have been synthesized and tested for antimicrobial activity. All new products were inactive against Gram negative bacteria and fungi. In contrast, among the compounds synthesized, 3b, 4b and 5b showed a moderate activity against Gram positive Staphylococcus aureus and Staphylococcus epidermidis. Of the present series, the 9-nitro-benzo[f]cinnoline N-oxide 5b possessed the highest activity especially against Trichomonas vaginalis (MIC = 3.9 g/ml).

Item Type:Article
ID Code:603
Status:Published
Refereed:Yes
Uncontrolled Keywords:Pyridazine N-oxides, antimicrobial activity, indeno[2,1-c]pyridazine, benzo[f]cinnoline
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Wiley
eISSN:1521-4184
Additional Information:Pubblicato online il 6 ottobre 2000.
Deposited On:18 Aug 2009 10:02

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