Gavini, Elisabetta and Juliano, Claudia Clelia Assunta and Mulè, Antonio Calogero and Pirisino, Gerolamo Antonio and Murineddu, Gabriele and Pinna, Gérard Aimé (2000) Pyridazine N-oxides. III Synthesis and in vitro antimicrobial properties of N-oxide derivatives based on tricyclic indeno[2,1-c]pyridazine and benzo[f]cinnoline systems. Archiv der Pharmazie, Vol. 333 (10), p. 341-346. eISSN 1521-4184. Article.
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A number of 9H-indeno[2,1-c]pyridazine N-oxides (3a - c) and benzo[f]cinnoline N-oxides (4,5a - c) have been synthesized and tested for antimicrobial activity. All new products were inactive against Gram negative bacteria and fungi. In contrast, among the compounds synthesized, 3b, 4b and 5b showed a moderate activity against Gram positive Staphylococcus aureus and Staphylococcus epidermidis. Of the present series, the 9-nitro-benzo[f]cinnoline N-oxide 5b possessed the highest activity especially against Trichomonas vaginalis (MIC = 3.9 g/ml).
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