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Use of Rituximab in autoimmune hemolytic anemia associated with non-hodgkin lymphomas

Fozza, Claudio and Longinotti, Maurizio Roberto (2011) Use of Rituximab in autoimmune hemolytic anemia associated with non-hodgkin lymphomas. Advances in Hematology, Vol. 2011 , p. 1-4. eISSN 1687-9112. Article.

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DOI: 10.1155/2011/960137

Abstract

The association between non-Hodgkin lymphomas and autoimmune disorders is a well-known event. Also autoimmune hemolytic anemia (AHA), although much more frequent in patients with chronic lymphocytic leukemia (CLL), has been described in this group of patients. In recent years, among the more traditional therapeutic options, rituximab, an anti-CD20monoclonal antibody, has shown interesting results in the treatment of primary AHA. Although this drug has been frequently used for AHA in patients with CLL, much less data are available on its use in NHL patients. However, considering that the main pathogenetic mechanism of AHA in course of lymphoproliferative disorders seems to be an antibody production directly or indirectly mediated by the neoplastic clone, this monoclonal antibody represents an ideal therapeutic approach. In this paper we will briefly describe some biological and clinical features of NHL-patients with AHA. We will then analyze some studies focusing on rituximab in primary AHA, finally reviewing the available literature on the use of this drug in NHL related AHA.

Item Type:Article
ID Code:5965
Status:Published
Refereed:Yes
Uncontrolled Keywords:Rituximab, non-Hodgkin lymphomas, autoimmune disorders
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
Publisher:Hindawi Publishing Corporation
eISSN:1687-9112
Copyright Holders:© 2011 Claudio Fozza and Maurizio Longinotti
Deposited On:19 Apr 2011 11:03

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