Giordano, Antonio and Rossi, Alessandra and Romano, Gaetano and Bagella, Luigi Marco (2007) Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy. Journal of Cellular Physiology, Vol. 213 (2), p. 403-406. eISSN 1097-4652. Article.
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Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment
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