Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy

Giordano, Antonio and Rossi, Alessandra and Romano, Gaetano and Bagella, Luigi Marco (2007) Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy. Journal of Cellular Physiology, Vol. 213 (2), p. 403-406. eISSN 1097-4652. Article.

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DOI: 10.1002/jcp.21225

Abstract

Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment

Item Type:	Article
ID Code:	596
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	PRb2/pl30, Spa310, cancer treatment, retinoblstoma (Rb) gene, cell cycle, cell proliferation
Subjects:	Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:	Wiley-Liss
eISSN:	1097-4652
Additional Information:	Pubblicato online il 20 agosto 2007.
Deposited On:	18 Aug 2009 10:02

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