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Cutaneous sporotrichoid leishmaniasis resistant to pentavalent antimonial therapy: complete resolution with itraconazole

Cozzani, Emanuele Claudio and Satta, Rosanna Rita and Fausti, V. and Cottoni, Francesca Maria Giovanna and Parodi, Aurora (2011) Cutaneous sporotrichoid leishmaniasis resistant to pentavalent antimonial therapy: complete resolution with itraconazole. Clinical and Experimental Dermatology, Vol. 36 (1), p. 49-51. eISSN 1365-2230. Article.

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DOI: 10.1111/j.1365-2230.2010.03855.x

Abstract

Sporotrichoid leishmaniasis is a sporadic form of cutaneous leishmaniasis, a protozoal infection, reported particularly in the Middle East. Clinically it occurs as nontender, subcutaneous, slightly erythematous nodules, often associated with lymphangitis, usually on exposed areas of the skin. Sometimes it occurs after treatment with a single dose of antimonials, and in older lesions, the biopsy can be negative for amastigotes. We report a case of cutaneous sporotrichoid leishmaniasis unresponsive to intralesional pentavalent antimonial therapy, which completely resolved after treatment with oral itraconazole. To our knowledge, this is only the third such case reported. We discuss the causes of dissemination of the nodular lesions and the negative results for amastigotes on re-biopsed lesions.

Item Type:Article
ID Code:5946
Status:Published
Refereed:Yes
Uncontrolled Keywords:Sporotrichoid leishmaniasis, amastigotes, antimonials
Subjects:Area 06 - Scienze mediche > MED/35 Malattie cutanee e veneree
Divisions:001 Università di Sassari > 03 Istituti > Dermatologia
Publisher:Blackwell / Wiley
eISSN:1365-2230
Copyright Holders:© 2010 The Author(s), Journal compilation © 2010 British Association of Dermatologists
Deposited On:15 Apr 2011 09:12

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