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From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway

Sun, Ang and Bagella, Luigi Marco and Tutton, Steven and Romano, Gaetano and Giordano, Antonio (2007) From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway. Journal of Cellular Biochemistry, Vol. 102 (6), p. 1400-1404. eISSN 1097-4644. Article.

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DOI: 10.1002/jcb.21609

Abstract

Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription factor E2F play an essential role in regulating cell cycle and, consequently, cell proliferation. This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression.

Item Type:Article
ID Code:589
Status:Published
Refereed:Yes
Uncontrolled Keywords:Tumor suppressor genes, Rb family, pRb2/p130, E2F, cell cycle, gene expression
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Wiley-Liss
eISSN:1097-4644
Additional Information:Pubblicato online il 2 novembre 2007.
Deposited On:18 Aug 2009 10:02

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