UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
A Small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo

Bagella, Luigi Marco and Sun, Ang and Tonini, Tiziana and Abbadessa, Giovanni and Cottone, G. and Paggi, Marco G. and De Luca, Antonio and Claudio, Pier Paolo and Giordano, Antonio (2007) A Small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo. Oncogene, Vol. 26 (13), p. 1829-1839. eISSN 1476-5594. Article.

Full text not available from this repository.

DOI: 10.1038/sj.onc.1209987

Abstract

One strategy in the development of anticancer therapeutics has been to arrest malignant proliferation through inhibition of the enzymatic activity of cyclin-dependent kinases (cdks), which are key regulatory molecules of the cell cycle. Over the past few years, numerous compounds with remarkable cdk inhibitory activity have been studied in cancer therapy, although it is very difficult to point out the best cdk to target. An excellent candidate appears to be cdk2, whose alteration is a pathogenic hallmark of tumorigenesis. The small molecule described in our study showed an inhibitory effect on the kinase activity of cdk2, a significant growth arrest observed in a colony formation assay and a reduction in the size of the tumor in nude mice, thus suggesting its potential role as a promising new type of mechanism-based antitumor drug, also for the treatment of hyperproliferative disorders.

Item Type:Article
ID Code:585
Status:Published
Refereed:Yes
Uncontrolled Keywords:PRb2/p130, small molecules, peptides, cdk2 inhibitor, kinase activity
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Nature Publishing Group
eISSN:1476-5594
Additional Information:Pubblicato online il 16 ottobre 2006.
Deposited On:18 Aug 2009 10:02

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page