Sechi, Gianpietro and Cocco, Giovanni Antonio and Errigo, Alessandra and Deiana, Luca and Rosati, Giulio and Agnetti, Virgilio and Paulus, Kai Stephan and Pes, Giovanni Mario (2007) Three sisters with very-late-onset major depression and parkinsonism. Parkinsonism & Related Disorders, Vol. 13 (2), p. 122-125. ISSN 1353-8020. Article.
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Familiar Parkinson's disease has an age of onset from the second to the sixth decade, whereas Wilson's disease (WD) usually presents in the first decade of life. We studied three sisters with a form of very-late-onset major depression and parkinsonism with probable linkage to ATP7B gene. Molecular studies demonstrated a nucleotide deletion at the 5′UTR region in a single allele of ATP7B gene. They did not have a family history of WD, or markers indicative for copper deposition in peripheral tissues. We suggest that single allele mutations of ATP7B gene may confer a susceptibility for late-onset major depression and parkinsonism.
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