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Targeted Biocompatible Nanoparticles for the Delivery of (−)-Epigallocatechin 3-Gallate to Prostate Cancer Cells

Sanna, Vanna and Pintus, Gianfranco and Roggio, Anna Maria and Punzoni, Stefania and Posadino, Anna Maria and Arca, Alessandro and Marceddu, Salvatore and Bandiera, Pasquale and Uzzau, Sergio and Sechi, Mario (2011) Targeted Biocompatible Nanoparticles for the Delivery of (−)-Epigallocatechin 3-Gallate to Prostate Cancer Cells. Journal of Medicinal Chemistry, Vol. 54 (5), p. 1321-1332. eISSN 1520-4804. Article.

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DOI: 10.1021/jm1013715

Abstract

Molecular targeted cancer therapy mediated by nanoparticles (NPs) is a promising strategy to overcome the lack of specificity of conventional chemotherapeutic agents. In this context, the prostate-specific membrane antigen (PSMA) has demonstrated a powerful potential for the management of prostate cancer (PCa). Cancer chemoprevention by phytochemicals is emerging as a suitable approach for the treatment of early carcinogenic processes. Since (−)-epigallocatechin 3-gallate (EGCG) has shown potent chemopreventive efficacy for PCa, we designed and developed novel targeted NPs in order to selectively deliver EGCG to cancer cells. Herein, to explore the recent concept of “nanochemoprevention”, we present a study on EGCG-loaded NPs consisting of biocompatible polymers, functionalized with small molecules targeting PSMA, that exhibited a selective in vitro efficacy against PSMA-expressing PCa cells. This approach could be beneficial for high risk patients and would fulfill a significant therapeutic need, thus opening new perspectives for novel and effective treatment for PCa.

Item Type:Article
ID Code:5771
Status:Published
Refereed:Yes
Uncontrolled Keywords:Nanoparticles, prostate cancer cells, EGCG, PCa, nanochemoprevention, PCa cells
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Area 05 - Scienze biologiche > BIO/16 Anatomia umana
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
002 Altri enti e centri di ricerca del Nord Sardegna > Porto Conte Ricerche, Alghero
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di scienze delle produzioni alimentari, Sassari
001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:American Chemical Society
eISSN:1520-4804
Deposited On:10 May 2011 17:13

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