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MyoD recruits the cdk9/cyclin T2 complex on Myogenic-genes regulatory regions

Giacinti, Cristina and Bagella, Luigi Marco and Puri, Pier Lorenzo and Giordano, Antonio and Simone, Cristiano (2005) MyoD recruits the cdk9/cyclin T2 complex on Myogenic-genes regulatory regions. Journal of Cellular Physiology, Vol. 206 (3), p. 807-813. eISSN 1097-4652. Article.

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DOI: 10.1002/jcp.20523

Abstract

During skeletal myogenesis, muscle-regulatory factors bHLH and MEF2 promote the expression of muscle-specific genes by recruiting several chromatin-modifying complexes on specific DNA regulatory sequences. A number of MyoD-interacting proteins have been reported, but whether they are recruited to the chromatin of myogenic loci, and the relationship with other chromatin bound proteins is unknown. We show that MyoD recruits cdk9/cyclin T2, together with the histone acetyltransferases p300 and PCAF, and the chromatin remodeling complex SWI/SNF, on promoters and enhancers of muscle-specific genes, and that this event correlates with the acetylation of histone tails, remodeling of chromatin, and phosphorylation of the C-terminal domain (CTD) of the RNA polymerase II at these elements.

Item Type:Article
ID Code:575
Status:Published
Refereed:Yes
Uncontrolled Keywords:MyoD proteins, cdk9/cyclin T2, histone acetyltransferases, skeletal myogenesis
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Wiley-Liss
eISSN:1097-4652
Additional Information:Pubblicato online il 21 ottobre 2005.
Deposited On:18 Aug 2009 10:02

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