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Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy

Busolin, Giorgia and Malacrida, Sandro and Bisulli, Francesca and Striano, Pasquale and Di Bonaventura, Carlo and Egeo, Gabriella and Pasini, Elena and Cianci, Vittoria and Ferlazzo, Edoardo and Bianchi, Amedeo and Coppola, Giangennaro and Elia, Maurizio and Mecarelli, Oriano and Gobbi, Giuseppe and Casellato, Susanna and Marchini, Marco and Binelli, Simona and Freri, Elena and Granata, Tiziana and Parmeggiani, Antonia and Posar, Annio and Vigliano, Piernanda and Boniver, Clementina and Aguglia, Umberto and Striano, Salvatore and Tinuper, Paolo and Giallonardo, Anna Teresa and Michelucci, Roberto and Nobile, Carlo (2011) Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy. Epilepsy Research, Vol. 94 (1-2), p. 110-116. eISSN 1872-6844. Article.

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DOI: 10.1016/j.eplepsyres.2011.01.010

Abstract

The KCNAB1 gene is a candidate susceptibility factor for lateral temporal epilepsy (LTE) because of its functional interaction with LGI1, the gene responsible for the autosomal dominant form of LTE. We investigated association between polymorphic variants across the KCNAB1 gene and LTE. The allele and genotype frequencies of 14 KCNAB1 intronic SNPs were determined in 142 Italian LTE patients and 104 healthy controls and statistically evaluated. Single SNP analysis revealed one SNP (rs992353) located near the 3′end of KCNAB1 slightly associated with LTE after multiple testing correction (odds ratio = 2.25; 95% confidence interval 1.26-4.04; P = 0.0058). Haplotype analysis revealed two haplotypes with frequencies higher in cases than in controls, and these differences were statistically significant after permutation tests (Psim = 0.047 and 0.034). One of these haplotypes was shown to confer a high risk for the syndrome (odds ratio = 12.24; 95% confidence interval 1.32-113.05) by logistic regression analysis. These results support KCNAB1 as a susceptibility gene for LTE, in agreement with previous studies showing that this gene may alter susceptibility to focal epilepsy.

Item Type:Article
ID Code:5743
Status:Published
Refereed:Yes
Uncontrolled Keywords:Lateral temporal epilepsy, KCNAB1, case-control study, SNPs, haplotype analysis
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Neuropsichiatria infantile
Publisher:Elsevier
eISSN:1872-6844
Deposited On:13 May 2011 12:20

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