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Using LASSO to estimate marker effects for genomic selection

Usai, Mario Graziano and Goddard, Mike E. and Hayes, Ben J. (2009) Using LASSO to estimate marker effects for genomic selection. Italian Journal of Animal Science, Vol. 8 (Suppl. 2), p. 168-170. eISSN 1828-051X. Article.

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DOI: 10.4081/ijas.2009.s2.168

Abstract

Here we suggest a least absolute shrinkage and selection operator (LASSO) approach to estimate the marker effects for genomic selection using the least angle regression (LARS) algorithm, modified to include a cross–validation step to define the best subset of markers to involve in the model. The LASSO-LARS was tested on simulated data which consisted of 5,865 individuals and 6,000 SNPs. The last generations of this dataset were the selection candidates. Using only animals from generations prior to the candidates, three approaches to splitting the population into training and validation sets for cross-validation were evaluated. Furthermore, different sizes of the validation sample were tested. Moreover, BLUP and Bayesian methods were carried out for comparison. The most reliable cross-validation method was the random splitting of overall population with a validation sample size of 50% of the reference population. The accuracy of the GEBVs (correlation with true breeding values) in the candidate population obtained by LASSO-LARS was 0.89 with 156 explanatory SNPs. This value was higher then those obtained by using BLUP and Bayesian methods, which were 0.75 and 0.84 respectively. It was concluded that LASSO-LARS approach is a good alternative way to estimate markers effects for genomic selection.

Item Type:Article
ID Code:5740
Status:Published
Refereed:Yes
Uncontrolled Keywords:Genomic-selection, SNP, LASSO, LARS
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/17 Zootecnica generale e miglioramento genetico
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AGRIS Sardegna, Olmedo > Dipartimento per la ricerca nelle produzioni animali > Settore genetica e biotecnologie
Publisher:Avenue media on behalf of Scientific Association of Animal Production (ASPA)
eISSN:1828-051X
Publisher Policy:Depositato per gentile concessione dell'ASPA
Additional Information:Relazione presentata al 18. Congresso nazionale ASPA, Palermo, 9-12 giugno 2009.
Deposited On:15 Mar 2011 13:57

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