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One polymorphism at the Stearoyl CoA Desaturase (SCD) gene is associated to CLA content of sheep milk fat

Miari, Sabrina and Usai, Mario Graziano and Sechi, Tiziana and Pernisa, Annalisa and Carta, Antonello (2009) One polymorphism at the Stearoyl CoA Desaturase (SCD) gene is associated to CLA content of sheep milk fat. Italian Journal of Animal Science, Vol. 8 (Suppl. 2), p. 108-110. ISSN 1828-051X. Article.

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DOI: 10.4081/ijas.2009.s2.108


On OAR 22 a highly significant QTL affecting the rate of desaturation of vaccenic acid (VA) to conjugated linoleic acid (CLA) in the mammary gland of sheep was found segregating on four dairy sheep families of a Sardinian x Lacaune back-cross population. The most likely location of the QTL was 35 cM corresponding to Stearoyl CoA Desaturase (SCD) gene location on the Australian Sheep Gene Map. The aim of this work was finding mutations along the SCD gene associated with the CLA/VA variability in sheep milk. The sequencing of a large part of the gene in the four informative sires allowed identifying one SNP in intron 4 (3295 C>T relative to Capra hircus SCD gene, GenBank Acc. no. AH011188). The sequencing of high and low phenotypic tails’ progeny from the most significant family showed a strong association of the found mutation with the CLA/VA variability.

Item Type:Article
ID Code:5737
Uncontrolled Keywords:QTL, CLA, SCD, SNP, Sardinia
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/17 Zootecnica generale e miglioramento genetico
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AGRIS Sardegna, Olmedo > Dipartimento per la ricerca nelle produzioni animali > Settore genetica e biotecnologie
Publisher:Avenue media on behalf of Scientific Association of Animal Production (ASPA)
Publisher Policy:Depositato per gentile concessione dell'ASPA
Additional Information:Relazione presentata al 18. Congresso nazionale ASPA, Palermo, 9-12 giugno 2009.
Deposited On:15 Mar 2011 11:59

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