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HCV-related hepatocellular carcinoma: from chronic inflammation to cancer

Castello, Giuseppe and Scala, Stefania and Palmieri, Giuseppe and Curley, Steven A. and Izzo, Francesco (2010) HCV-related hepatocellular carcinoma: from chronic inflammation to cancer. Clinical Immunology, Vol. 134 (3), p. 237-250. eISSN 1521-7035. Article.

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DOI: 10.1016/j.clim.2009.10.007

Abstract

Hepatitis C virus (HCV) infection is a worldwide health problem because of its incidence and pathogenicity. It might evolve into chronic disease, cirrhosis, and/or hepatocellular carcinoma (HCC) and the outcome is mainly determined by the host immune response. For viral clearance, combined innate and adaptive immune responses are required; resolution requires a vigorous, durable, polyclonal CD4+ and CD8+ T-cell response, with an increase in virus-specific CD8+ T cells or cytotoxic T lymphocytes. Failure of efficient immune response can lead to chronic inflammation, tissue remodeling through cell growth, apoptosis and/or necrosis and induction of oxidative stress. Development of fibrosis and/or cirrhosis plus a microenvironment conducive to genomic instability mutations will promote neoplastic transformation. System governance derives from cellular (regulatory cells) and humoral (cytokines and chemokines) immune networks. Therefore, HCC pathogenesis may be a model to study the disease progression from chronic inflammation to cancer allowing design of new strategies targeting the immune response, thereby modifying disease outcome.

Item Type:Article
ID Code:5709
Status:Published
Refereed:Yes
Uncontrolled Keywords:Hepatitis C virus, hepatocellular carcinoma, immune response, inflammation
Subjects:Area 06 - Scienze mediche > MED/06 Oncologia medica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Academic Press / Elsevier
eISSN:1521-7035
Copyright Holders:© 2009 Elsevier
Deposited On:04 Mar 2011 10:06

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