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Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis (hydroxymethyl)-1-methyl-7- and 7,8 -substituted-benzo[g]indoles

Pinna, Gérard Aimé and Pirisi, Maria Antonietta and Sechi, Mario and Paglietti, Giuseppe (1998) Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis (hydroxymethyl)-1-methyl-7- and 7,8 -substituted-benzo[g]indoles. Il Farmaco, Vol. 53 (2), p. 161-168. ISSN 0014-827X. Article.

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DOI: 10.1016/S0014-827X(97)00016-5

Abstract

A series of various bis(hydroxymethyl) carbamate derivatives of 7-mono- and 7,8-disubstituted- l-methyl-benzo[g]indoles was prepared in order to evaluate their cytostatic and cytotoxic activities in vitro. Compounds 2a-h showed significant tumor growth inhibition activity and were more potent than the 4,5-dihydrobenzo[g] indole analogues previously described. Compound 2a was the most active in this series, showing high activity and selectivity for some human cancer cell lines in the National Cancer Institute screen.

Item Type:Article
ID Code:568
Status:Published
Refereed:Yes
Uncontrolled Keywords:Benzo[g]indole biscarbamates, anticancer activity, cytotoxic activity, cytostatic activity
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier
ISSN:0014-827X
Deposited On:18 Aug 2009 10:02

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