UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Hydrodehalogenation of halogenated pyridines and quinolines by sodium borohydride/N,N,N′,N′-tetramethylethylenediamine under palladium catalysis

Chelucci, Giorgio Adolfo (2010) Hydrodehalogenation of halogenated pyridines and quinolines by sodium borohydride/N,N,N′,N′-tetramethylethylenediamine under palladium catalysis. Tetrahedron Letters, Vol. 51 (12), p. 1562-1565. ISSN 0040-4039. Article.

Full text not available from this repository.

DOI: 10.1016/j.tetlet.2010.01.053

Abstract

A protocol for the hydrodehalogenation of halogenated pyridines and quinolines by the sodium borohydride/N,N,N′,N′-tetramethylethylenediamine (NaBH4–TMEDA) system under palladium catalysts is reported. Catalytic amounts of [1,1′-bis(diphenylphosphino)ferrocene] dichloropalladium(II) in combination with NaBH4–TMEDA rapidly hydrodehalogenate chloro(bromo)-pyridines and -quinolines at room temperature in quantitative yields. Chemoselective reduction of 4,7-dichloroquinoline affords 7-chloroquinoline as the sole product in almost quantitative yield. Moreover, palladium(II) acetate-triphenylphosphine and NaBH4–TMEDA are able to reduce efficiently reactive bromo-pyridines and -quinolines.

Item Type:Article
ID Code:5664
Status:Published
Refereed:Yes
Uncontrolled Keywords:Hydrodehalogenation, reduction, halopyridines, haloquinolines, palladium catalysts, sodium borohydride
Subjects:Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Pergamon / Elsevier
ISSN:0040-4039
Copyright Holders:© 2010 Elsevier
Deposited On:08 Mar 2011 12:10

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page