Histamine modified 2′-deoxyriboadenosine – Potential copper binding site in DNAzymes

Lodyga-Chruscinska, Elzbieta and Sochacka, Elzbieta and Smuga, Damian and Chruscinski, Longin and Micera, Giovanni and Sanna, Daniele and Turek, Monika and Gasiorkiewicz, Monika (2010) Histamine modified 2′-deoxyriboadenosine – Potential copper binding site in DNAzymes. Journal of Inorganic Biochemistry, Vol. 104 (5), p. 570-575. eISSN 1873-3344. Article.

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DOI: 10.1016/j.jinorgbio.2010.01.009

Abstract

Copper(II) complexes of histamine modified 2′-deoxyriboadenosine (N-[(9-β-D-2′-deoxyribofuranosylpurin-6-yl)-carbamoyl]histamine) ligand were studied by potentiometric, UV–visible and EPR techniques. The imidazole residue of the ligand was described as the main binding site forming mono-, bis-(ligand) and dimer complexes, but the interactions between adenosine nitrogen N(1) and carbamoyl nitrogen atoms and the copper(II) ion also were detected. This is the first report evaluating the coordinating ability of such a modified adenosine ligand towards copper(II) ion. Our findings suggest that histamine modified 2′-deoxyriboadenosine

Item Type:	Article
ID Code:	5657
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	DNAzymes, histamine modified 2′-deoxyriboadenosine, Cu(II) complex
Subjects:	Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Chimica 002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:	Elsevier
eISSN:	1873-3344
Deposited On:	08 Mar 2011 12:55

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