Lodyga-Chruscinska, Elzbieta and Sochacka, Elzbieta and Smuga, Damian and Chruscinski, Longin and Micera, Giovanni and Sanna, Daniele and Turek, Monika and Gasiorkiewicz, Monika (2010) Histamine modified 2′-deoxyriboadenosine – Potential copper binding site in DNAzymes. Journal of Inorganic Biochemistry, Vol. 104 (5), p. 570-575. eISSN 1873-3344. Article.
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Copper(II) complexes of histamine modified 2′-deoxyriboadenosine (N-[(9-β-D-2′-deoxyribofuranosylpurin-6-yl)-carbamoyl]histamine) ligand were studied by potentiometric, UV–visible and EPR techniques. The imidazole residue of the ligand was described as the main binding site forming mono-, bis-(ligand) and dimer complexes, but the interactions between adenosine nitrogen N(1) and carbamoyl nitrogen atoms and the copper(II) ion also were detected. This is the first report evaluating the coordinating ability of such a modified adenosine ligand towards copper(II) ion. Our findings suggest that histamine modified 2′-deoxyriboadenosine
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