UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Dopamine on D2-like receptors “reboosts” dopamine D1-like receptor-mediated behavioural activation in rats licking for sucrose

D'Aquila, Paolo Stefano (2010) Dopamine on D2-like receptors “reboosts” dopamine D1-like receptor-mediated behavioural activation in rats licking for sucrose. Neuropharmacology, Vol. 58 (7), p. 1085-1096. eISSN 1873-7064. Article.

Full text not available from this repository.

DOI: 10.1016/j.neuropharm.2010.01.017

Abstract

Background
The analysis of licking microstructure provides measures, such as duration and number of licking bouts, which might reveal the former an evaluation process and the latter an approach response. Dopamine D2-like receptor antagonists reduce the duration of licking bouts and mimic the effect of reducing sucrose concentration, while conflicting results are reported on the effects of dopamine D1-like receptor antagonists. The aim of this study is to examine the roles of dopamine D1-like and D2-like receptors in the activation of reward-associated responses and in reward evaluation, through the study of licking microstructure.
Methods
The effects of the dopamine D2-like receptor antagonists raclopride (0.025–0.25 mg/kg), the D1-like antagonist SCH 23390 (0.01–0.04 mg/kg) and the antipsychotic drug haloperidol (0.02–0.05 mg/kg), have been examined on the microstructure of licking for a 10% sucrose solution in rats.
Results
The results confirm that dopamine D2-like receptor antagonists reduce the duration of licking bouts and reveal that while SCH 23390 reduced licking exclusively by reducing bout number, raclopride produced on this measure an extinction mimicry effect similar to that observed in instrumental responding for different rewards.
Discussion
These results are consistent with the hypothesis that the level of activation of the responses to the reward-associated cues depends on dopamine D1-like receptor stimulation, and is updated, or “reboosted”, on the basis of a dopamine D2-like receptor-mediated evaluation process occurring during the consummatory transaction with the reward.

Item Type:Article
ID Code:5654
Status:Published
Refereed:Yes
Uncontrolled Keywords:Reward, dopamine receptor, dopamine, motivation, behaviour, activation
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Pergamon / Elsevier
eISSN:1873-7064
Copyright Holders:© 2010 Elsevier
Deposited On:08 Mar 2011 13:12

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page