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Interferon-γ release assay in people infected with immunodeficiency virus

Bua, Alessandra and Molicotti, Paola and Ruggeri, Melania and Madeddu, Giordano and Ferrandu, Giovanna and Mura, Maria Stella Anna and Zanetti, Stefania Anna Lucia (2011) Interferon-γ release assay in people infected with immunodeficiency virus. Clinical Microbiology and Infection, Vol. 17 (3), p. 402-404. eISSN 1469-0691. Article.

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DOI: 10.1111/j.1469-0691.2010.03251.x


The present study aimed to use QuantiFERON TB Gold in tube (Cellestis Limited, Carnegie, Victoria, Australia) as a tool for the screening for tubercular infection in HIV-positive patients. Seventy-three HIV-positive subjects were tested. For each individual, QuantiFERON TB in tube was performed. The immunoassay was negative in 53 subjects, positive in eight and indeterminate in 12. The data obtained indicate that factors such as the CD4 cell count and their percentage, as well as the stage of the disease, could affect the performance of the interferon-γ release assay in populations at risk such as HIV-positive subjects.

Item Type:Article
ID Code:5652
Uncontrolled Keywords:CD4 cell count, HIV, HIV viral load, QuantiFERON, tuberculosis
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
Publisher:Blackwell / Wiley
Copyright Holders:© 2010 University of Sassari, Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases
Deposited On:28 Feb 2011 08:13

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