Abstract

This special issue of the Journal of Molecular Aspects of Medicine has not been conceived to propose a comprehensive overview of all recent advances in the personalized molecular therapy of tumor. The aim of this issue is to focus on some of the major topics, treated by experts in the field, devoted to looking to the future of cancer therapy. The lesson for future developments is the need to expand our knowledge on the dysregulation of cellular signal transduction mechanisms, involved in cancer development and progression, in order to identify novel “druggable” targets and treatments based on patients’ particular genetic signatures. Moreover, the effects of the combined inhibition of different pathways, the correlations between molecular dysregulation and clinical response to therapy, and the methods to select the patients which could take advantage from a personalized molecular therapy are major themes treated in the present special issue, which can hopefully provide stimulus for further advances in the field.

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