Spanu, Pietro and De Candia, Cristina and Ulgheri, Fausta (2010) 5-Trihydroxypropyl-dihydrouracil derivatives as precursors of 1-azasugars: application to the stereoselective synthesis of d-galacto-isofagomine. Tetrahedron Letters, Vol. 51 (18), p. 2400-2402. ISSN 0040-4039. Article.
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A new route for the synthesis of isofagomine analogues has been carried out by using as precursors enantiopure 5-trihydroxypropyl-dihydrouracil derivatives obtained from aldol-type addition of 1,3-dibenzyl-dihydrouracil to isopropylidene-protected glyceraldehyde. The synthesis of d-galacto-isofagomine is reported.
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