5-Trihydroxypropyl-dihydrouracil derivatives as precursors of 1-azasugars: application to the stereoselective synthesis of d-galacto-isofagomine

Spanu, Pietro and De Candia, Cristina and Ulgheri, Fausta (2010) 5-Trihydroxypropyl-dihydrouracil derivatives as precursors of 1-azasugars: application to the stereoselective synthesis of d-galacto-isofagomine. Tetrahedron Letters, Vol. 51 (18), p. 2400-2402. ISSN 0040-4039. Article.

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DOI: 10.1016/j.tetlet.2010.02.093

Abstract

A new route for the synthesis of isofagomine analogues has been carried out by using as precursors enantiopure 5-trihydroxypropyl-dihydrouracil derivatives obtained from aldol-type addition of 1,3-dibenzyl-dihydrouracil to isopropylidene-protected glyceraldehyde. The synthesis of d-galacto-isofagomine is reported.

Item Type:	Article
ID Code:	5645
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	1-Azasugars, galacto-Isofagomine
Subjects:	Area 03 - Scienze chimiche > CHIM/06 Chimica organica
Divisions:	002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:	Pergamon / Elsevier
ISSN:	0040-4039
Copyright Holders:	© 2010 Elsevier
Deposited On:	08 Mar 2011 13:24

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