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A Multicentre Phase II study of non-pegylated liposomal doxorubicin in combination with trastuzumab and docetaxel as first-line therapy in metastatic breast cancer

Venturini, Marco and Bighin, Claudia and Puglisi, Fabio and Olmeo, Nina and Aitini, Enrico and Colucci, Giuseppe and Garrone, Ornella and Paccagnella, Adriano and Marini, Giovanni and Crinò, Lucio and Mansutti, Mauro and Baconnet, Bruno and Barbato, Alfredo and Del Mastro, Lucia (2010) A Multicentre Phase II study of non-pegylated liposomal doxorubicin in combination with trastuzumab and docetaxel as first-line therapy in metastatic breast cancer. The Breast, Vol. 19 (5), p. 333-338. eISSN 1532-3080. Article.

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DOI: 10.1016/j.breast.2010.01.018

Abstract

To evaluate the cardiotoxicity, general toxicity, and activity of non-pegylated liposomal doxorubicin, in combination with docetaxel and trastuzumab, as first-line therapy in metastatic breast cancer.
Thirty-one patients with metastatic human epidermal growth factor receptor 2-overexpressing breast cancer, who had not previously received chemotherapy for metastatic disease, received non-pegylated liposomal doxorubicin (50 mg/m2), docetaxel (75 mg/m2) and trastuzumab (2 mg/kg/week) for up to eight cycles, followed by trastuzumab alone for up to 52 weeks. Cardiotoxicity was defined as a decrease in left ventricular ejection fraction (LVEF) to below 45%, or a decrease in LVEF of at least 20% from baseline.
Mean LVEF was maintained at baseline level also in the subset of patients who had received anthracycline previously. Cardiotoxicity developed in three patients during the treatment cycles, and in two further patients after the end of the study. The most common adverse events were haematological toxicity, alopecia, asthenia and fever. The best overall response rate was 65.5%. Median time to progression was 13.0 months.
The combination of non-pegylated liposomal doxorubicin, docetaxel and trastuzumab combines acceptable cardiac and general toxicity and promising activity as first-line therapy in metastatic breast cancer.

Item Type:Article
ID Code:5641
Status:Published
Refereed:Yes
Uncontrolled Keywords:Non-pegylated liposomal doxorubicin, docetaxel, Trastuzumab, phase II trial, cardiotoxicity, metastatic breast cancer
Subjects:Area 06 - Scienze mediche > MED/06 Oncologia medica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Ospedale civile SS. Annunziata > Ambulatorio oncologia medica
Publisher:Churchill Livingstone / Elsevier
eISSN:1532-3080
Copyright Holders:© 2010 Elsevier
Deposited On:08 Mar 2011 13:46

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