Corona, Paola and Vitale, Gabriella and Loriga, Mario and Paglietti, Giuseppe (2000) Quinoxaline chemistry: Part 13: 3-carboxy-2-benzylamino-substituted quinoxalines and N-[4-[(3-carboxyquinoxalin-2-yl) aminomethyl]benzoyl]-L -glutamates: synthesis and evaluation of in vitro anticancer activity. Il Farmaco, Vol. 55 (2), p. 77-86. ISSN 0014-827X. Article.
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Among a new series of 28 3-carboxy or carbethoxy quinoxalines bearing a substituted benzylamino or N-[4-(aminomethyl)benzoyl]glutamate group on position 2 of the ring and various substituents at C-6, 7 positions, 21 were selected at the National Cancer Institute for evaluation of their in vitro anticancer activity. The results obtained seem to confirm that the carboxy or carbethoxy group on position 3 is not helpful, with a few exceptions, for the anticancer activity.
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