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De novo everolimus-based therapy in renal transplant recipients: effect on proteinuria and renal prognosis

Loriga, Giacomina and Ciccarese, Milco and Pala, Pier Giorgio and Satta, Rita P. and Fanelli, Vincenzo and Manca, Maria Luisa and Serra, Giovanna and Dessole, Paolo and Cossu, Maria (2010) De novoeverolimus-based therapy in renal transplant recipients: effect on proteinuria and renal prognosis. Transplantation Proceedings, Vol. 42 (4), p. 1297-1302. eISSN 1873-2623. Article.

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DOI: 10.1016/j.transproceed.2010.03.120

Abstract

Background
In large-scale clinical trials, the proliferation signal inhibitor (PSI) everolimus (EVL) combined with cyclosporine (CsA) and steroids, has been shown to be efficacious among de novo renal transplant recipients. Development of proteinuria has been shown to be an important predictor of renal dysfunction after conversion from CsA to a PSI-based regimen, and a key marker of allograft disease progression. Whether EVL de novo treatment is associated with a similar proteinuric effect is still under investigation.
Methods
We compared the development of proteinuria among a cohort of 24 renal transplant recipients who were prescribed EVL (3 mg/d; n = 12; high-dose group) or 1.5 mg/d (n = 12; standard-dose group), in association with CsA, versus third control cohort of 12 patients who received mycophenolate mofetil (control group). EVL doses were adjusted to achieve trough blood levels of 3–8 ng/mL and 8–12 ng/mL among the standard and high-dose groups, respectively. We assessed renal function and protein excretion over a 2-year observation.
Results
The high-dose group showed a trend toward greater proteinuria than the standard-dose on control groups. They showed significantly greater proteinuria from 9 months until 2 years; 0.86 ± 0.5, 0.5 ± 0.3, 0.47 ± 0.2 g/24 h (P = .03 and P = .02, respectively, at 24 months). Mean proteinuria significantly correlated with mean EVL doses (n = .73; P = .0001). Concomitantly, the estimated glomerular filtration rate (eGFR) was significantly lower among patients treated with EVL 3.0 versus 1.5 mg/d (53.7 ± 24 vs 73.04 ± 17.6 mL/min; P = .037). Among patients in the standard-dose, the eGFR was consistently higher than the control group (62.6 ± 29 mL/min).
Conclusion
EVL/CsA therapy is a safe alternative regimen for de novo renal transplant recipients. Higher EVL doses are correlated with greater increases in proteinuria. The standard EVL dose seems to be useful treatment strategy to prevent acute rejection episodes, with a better renal prognosis in the long term.

Item Type:Article
ID Code:5592
Status:Published
Refereed:Yes
Uncontrolled Keywords:Immunosuppressive agent, inhibitor (PSI), everolimus (EVL), proteinuria, EVL/CsA therapy
Subjects:Area 06 - Scienze mediche > MED/14 Nefrologia
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Ospedale civile SS. Annunziata > Ambulatorio nefrologia e dialisi
Publisher:Elsevier
eISSN:1873-2623
Deposited On:16 Mar 2011 17:39

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