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Individualized treatment with combination of Peg-interferon alpha 2b and ribavirin in patients infected with HCV genotype 3

Mangia, Alessandra and Bandiera, Franco and Montalto, Giuseppe and Mottola, Leonardo and Piazzolla, Valeria and Minerva, Nicola and Pellicelli, Adriano and Ricci, Giovanni Luciano and Cela, Ester Marina and Carretta, Vito and Scotto, Gaetano and Bacca, Donato and Annicchiarico, Brigida Eleonora and Romano, Mario and Russello, Maurizio and Barbarini, Giorgio and Agostinacchio, Ernesto and Andriulli, Angelo (2010) Individualized treatment with combination of Peg-interferon alpha 2b and ribavirin in patients infected with HCV genotype 3. Journal of Hepatology, Vol. 53 (6), p. 1000-1005. ISSN 0168-8278. Article.

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DOI: 10.1016/j.jhep.2010.04.042

Abstract

Background & Aims
The benefit of individualizing treatment for patients with genotype 3 HCV infection on the basis of viral clearance at week 4 (wk4-R) has not been firmly established.
Methods
Four hundred and fourteen patients received Peg-interferon alpha-2b plus 1000–1200 mg of ribavirin daily according with body weight > or <75 kg. Patients were randomized to standard 24 weeks (Std24) or to a 12 or 36 weeks variable treatment duration (Var12/36). In the variable treatment arm, patients with or without wk4-R were allocated to either 12 or 36 weeks duration.
Results
At treatment week 4, HCV RNA was undetectable in 262 patients (63.3%), 136 in the Std24, and 126 in the Var12/36 group (p = 0.41). In patients with wk4-R, end-of-treatment (EOT) responses were 80.4% (CI 85.4–95.3) and 97.6% (CI 94.9–99.9) in the two arms, respectively (p = 0.019). In patients without wk4-R, corresponding rates were 61.9% (50.6–73.2) and 75.3% (CI 65.9–84.6) (p = 0.08). SVR was attained in 302 patients, 71.4% (CI 65.3–77.6) in the St24 group and 74.3% (CI 58.4–80.3) in the variable 12/36 arm. Among patients with wk4-R, SVR was 81.6% (CI 75.1–88.1) and 82.5% (75.9–89.1), respectively. In patients without wk4-R, SVR amounted to 52.1% (CI 40.4–63.7) and 61.7 (CI 51.1–72.3) in the two arms (p = 0.25).
Conclusions
HCV genotype 3 patients with week4-R may be treated safely with 12 weeks of therapy, provided that sufficiently high doses of ribavirin are administered. For patients still viremic at treatment week 4, SVR rates were numerically higher after 36 weeks of treatment than after the currently recommended 24 weeks.

Item Type:Article
ID Code:5558
Status:Published
Refereed:Yes
Uncontrolled Keywords:HCV genotype 3, Ribavirin, Peg-interferon, short treatment
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Ospedale civile SS. Annunziata
Publisher:Elsevier Science Ireland
ISSN:0168-8278
Deposited On:07 Mar 2011 17:57

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