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Gender-specific features of plasmatic and circulating cell alterations as risk factors in cardiovascular disease

Straface, Elisabetta and Lista, Pasquale and Gambardella, Lucrezia and Franconi, Flavia and Malorni, Walter (2010) Gender-specific features of plasmatic and circulating cell alterations as risk factors in cardiovascular disease. Fundamental & Clinical Pharmacology, Vol. 24 (6), p. 665-674. eISSN 1472-8206. Article.

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DOI: 10.1111/j.1472-8206.2010.00860.x


Cardiovascular disease (CVD) is the leading cause of death in the Western countries. Several epidemiological studies have hypothesized a gender disparity in the pathogenesis and progression of CVD. For instance, women develop CVD when they are about 10 years older than men and, typically, after menopause. However, considering that women are often excluded from research studies, sex differences in CVD remains a frontier for discovery. Very important is thus the identification of risk factors allowing us to diagnose or predict cardiovascular events taking into account gender disparities. In this review, we will examine some of the major challenges in the discovery and validation of cardiovascular biomarkers in a gender perspective. In particular, we will consider classical (hypertension, smoking, diabetes, dyslipidemia, physical inactivity) and novel (inflammation markers, markers of endothelial dysfunction, markers of coronary disease) risk factors reporting gender differences. The aim of this review was to provide an overview on current knowledge on sex-associated cardiovascular determinants with the aim to improve CVD diagnostic and prognostic clinical courses and to develop new and gender-biased prevention strategies.

Item Type:Article
ID Code:5550
Uncontrolled Keywords:Cardiovascular disease, gender, markers, risk factors
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Blackwell / Wiley
Copyright Holders:© 2010 The Authors Fundamental and Clinical Pharmacology, © 2010 Société Française de Pharmacologie et de Thérapeutique
Deposited On:16 Feb 2011 08:34

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