De Socio, Giuseppe Vittorio Luigi and Ricci, Elena and Parruti, Giustino and Maggi, Paolo and Madeddu, Giordano and Quirino, Tiziana and Bonfanti, Paolo (2010) Chronological and biological age in HIV infection. Journal of Infection, Vol. 61 (5), p. 428-430. ISSN 0163-4453. Article.
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Several studies have so far documented the dramatic impact of highly active antiretroviral therapy (HAART) in improving survival estimates of HIV-infected patients. Within such a scenario, the growing impact of cardiovascular disease and accelerated biological aging is of particular concern. Indeed, HIV-infected patients are generally considered a special population experiencing an acceleration of the aging process, as well as a substantial burden of additional co-morbidity. An important role in determining premature aging has been attributed to conventional cardiovascular risk factors, as these are widely prevalent in HIV-infected people. A better evaluation of their impact may be provided by the estimate of vascular age as calculated by a new sex-specific multivariable risk factor algorithm derived from the Framingham Heart Study. It includes age, total and HDL-cholesterol, blood pressure, diabetes and tobacco use. This equation may be applied to obtain a derived estimate of vascular age in the general population. The aim of our present investigation was to estimate the difference between chronological age and vascular age, calculated using the Framingham equation, in a large cohort of HIV-infected patients. In 2 recent multicenter Italian studies, “SIM-One” and “HERMES”, we collected clinical and laboratory data, including information on cardiovascular risk factors, on 1243 HIV-infected patients (most on HAART) and 317 antiretroviral naïve HIV patients, respectively. The main characteristics of evaluated patients are summarized in Table 1. The estimated vascular age was higher than chronological age in both groups (+6.0 and +4.2 in SIM-One and HERMES, respectively).
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