Piras, Sandra and Loriga, Mario and Paglietti, Giuseppe (2002) Quinoxaline chemistry: Part 14: 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-L -glutamates as analogues-homologues of classical antifolate agents: synthesis and evaluation of in vitro anticancer activity. Il Farmaco, Vol. 57 (1), p. 1-8. ISSN 0014-827X. Article.
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Among a new series of 26 4-(3-substituted-2-quinoxalylamino)phenylacetates and 4-(3-substituted-2-quinoxalylamino)phenylacetyl-L -glutamates, eight were selected at NCI for evaluation of their in vitro anticancer activity. The results obtained in comparison with the corresponding nor-compounds series seem to indicate that this type of homologation is not helpful.
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