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A Novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms

D'Antona, Nicola and Morrone, Raffaele and Bovicelli, Paolo and Gambera, Giovanni and Kubáč, David and Martínková, Ludmila (2010) A Novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms. Tetrahedron: Asymmetry, Vol. 21 (20), p. 2448-2454. eISSN 1362-511X. Article.

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DOI: 10.1016/j.tetasy.2010.10.010

Abstract

A new route to synthesize cyclophellitol and epi-cyclophellitol from racemic starting materials in enantiopure forms has been developed. The synthesis involves a multi-enzymatic biotransformation pathway of the novel cyano-cyclitol (1R,4S,5R,6R)/(1S,4R,5S,6S)-4,5,6-trihydroxycyclohex-2-enecarbonitrile by a cooperative use of lipase, nitrile hydratase, and amidase.

Item Type:Article
ID Code:5475
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cyclophellitol, epi-cyclophellitol, chiral cyclitols, multi-enzymatic biotransformation
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:Pergamon / Elsevier
eISSN:1362-511X
Deposited On:21 Feb 2011 10:55

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