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HLA polymorphisms in Italian children with autism spectrum disorders: results of a family based linkage study

Guerini, Franca R. and Bolognesi, Elisabetta and Chiappedi, Matteo and De Silvestri, Annalisa and Ghezzo, Alessandro and Zanette, Michela and Rusconi, Beatrice and Manca, Salvatorica and Sotgiu, Stefano and Agliardi, Cristina and Clerici, Mario Salvatore (2011) HLA polymorphisms in Italian children with autism spectrum disorders: results of a family based linkage study. Journal of Neuroimmunology, Vol. 230 (1-2), p. 135-142. eISSN 1872-8421. Article.

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DOI: 10.1016/j.jneuroim.2010.10.019

Abstract

To verify correlations between HLA and autism spectrum disorders (ASD) we studied 61 Italian families with an ASD child; results showed such correlation in 65% of cases. Case–control and TDT analysis of intrafamilial transmission of SNPs, Msats, and HLA markers surrounding the α and β blocks, indicated significant positive associations for MOGc*131 and D6S2239*105 alleles in ASD, and a negative association of MIB *332 allele in healthy siblings. Polymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD. MOGc and MIB loci are linked with ASD in Italian patients.

Item Type:Article
ID Code:5470
Status:Published
Refereed:Yes
Uncontrolled Keywords:Autistic spectrum disorder, family based study, MHC, microsatellite, single nucleotide polymorphism
Subjects:Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 03 Istituti > Neuropsichiatria infantile
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Elsevier
eISSN:1872-8421
Copyright Holders:© 2010 Elsevier
Deposited On:21 Feb 2011 10:35

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