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Cardiac β1-adrenoceptor expression in two stress-induced cardiomyopathy-related deaths

D'Errico, Stefano and Neri, Margherita and Nieddu, Antonio and Mazzeo, Elena and Riezzo, Irene and Turillazzi, Emanuela and Fineschi, Vittorio (2011) Cardiac β1-adrenoceptor expression in two stress-induced cardiomyopathy-related deaths. Forensic Science International, Vol. 207 (1-3), p. e8-e11. eISSN 1872-6283. Article.

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DOI: 10.1016/j.forsciint.2010.11.007

Abstract

Stress-induced cardiomyopathy (SICM) is characterized by transient systolic dysfunction of the apical and/or midventricular myocardial segments in the absence of obstructive coronary artery disease and is unique in that it can manifest itself after acute emotional stress. Excessive amounts of catecholamines released from sympathetic nerve endings as well as from the adrenal medulla under stressful conditions are considered to produce intracellular Ca2+ overload and cardiac dysfunction through the β1-adrenoceptor signal transduction pathway. We describe the clinical and pathomorphological findings in two stress-induced cardiomyopathy fatal cases. Levels of catecholamines and their metabolites in urine samples were assessed too.
Morphological patterns seen in SICM result from the complex interplay between sympathetic innervations, β-receptor density and function and catecholamine sensitivity.

Item Type:Article
ID Code:5441
Status:Published
Refereed:Yes
Uncontrolled Keywords:Stress-induced cardiomyopathy, emotional stress related death, catecholamine cardiac toxicity
Subjects:Area 06 - Scienze mediche > MED/43 Medicina legale
Divisions:001 Università di Sassari > 03 Istituti > Medicina legale e medicina del lavoro
Publisher:Elsevier Science Ireland
eISSN:1872-6283
Deposited On:21 Feb 2011 10:48

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