D'Errico, Stefano and Neri, Margherita and Nieddu, Antonio and Mazzeo, Elena and Riezzo, Irene and Turillazzi, Emanuela and Fineschi, Vittorio (2011) Cardiac β1-adrenoceptor expression in two stress-induced cardiomyopathy-related deaths. Forensic Science International, Vol. 207 (1-3), p. e8-e11. eISSN 1872-6283. Article.
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Stress-induced cardiomyopathy (SICM) is characterized by transient systolic dysfunction of the apical and/or midventricular myocardial segments in the absence of obstructive coronary artery disease and is unique in that it can manifest itself after acute emotional stress. Excessive amounts of catecholamines released from sympathetic nerve endings as well as from the adrenal medulla under stressful conditions are considered to produce intracellular Ca2+ overload and cardiac dysfunction through the β1-adrenoceptor signal transduction pathway. We describe the clinical and pathomorphological findings in two stress-induced cardiomyopathy fatal cases. Levels of catecholamines and their metabolites in urine samples were assessed too.
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