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Quinoxaline chemistry: Part 17: Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-{[4-(substituted 2-quinoxalinyloxy) phenyl] acetyl} glutamates analogs of methotrexate: synthesis and evaluation of in vitro anticancer activity

Piras, Sandra and Loriga, Mario and Paglietti, Giuseppe (2004) Quinoxaline chemistry: Part 17: Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-{[4-(substituted 2-quinoxalinyloxy) phenyl] acetyl} glutamates analogs of methotrexate: synthesis and evaluation of in vitro anticancer activity. Il Farmaco, Vol. 59 (3), p. 185-194. ISSN 0014-827X. Article.

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DOI: 10.1016/j.farmac.2003.11.014

Abstract

Fourteen out of 21 quinoxaline derivatives described in the present paper were selected at NCI for evaluation of their in vitro anticancer activity. Preliminary screening showed that some derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10–5 and 10–4 M concentrations. Interesting selectivities were also recorded between 10–8 and 10–6 M for the compounds 9 and 13.

Item Type:Article
ID Code:539
Status:Published
Refereed:Yes
Uncontrolled Keywords:Anticancer activity, quinoxaline derivatives
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Elsevier
ISSN:0014-827X
Deposited On:18 Aug 2009 10:02

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