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Inhibition of RNA helicases of ssRNA+ virus belonging to Flaviviridae, Coronaviridae and Picornaviridae families

Briguglio, Irene and Piras, Sandra and Corona, Paola and Carta, Antonio (2011) Inhibition of RNA helicases of ssRNA+ virus belonging to Flaviviridae, Coronaviridae and Picornaviridae families. International Journal of Medicinal Chemistry, Vol. 2011 , p. 1-22. eISSN 2090-2077. Article.

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DOI: 10.1155/2011/213135

Abstract

Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one or more of the following mechanisms: inhibition of the NTPase activity, by interferences with ATP binding and therefore by limiting the energy required for the unwinding and translocation, or by allosteric mechanism and therefore by stabilizing the conformation of the enzyme in low helicase activity state; inhibition of nucleic acids binding to the helicase; inhibition of coupling of ATP hydrolysis to unwinding; inhibition of unwinding by sterically blocking helicase translocation. Recently, by in vitro screening studies, it has been reported that several benzotriazole, imidazole, imidazodiazepine, phenothiazine, quinoline, anthracycline, triphenylmethane, tropolone, pyrrole, acridone, small peptide, and Bananin derivatives are endowed with helicase inhibition of pathogen viruses belonging to Flaviviridae, Coronaviridae, and Picornaviridae families.

Item Type:Article
ID Code:5384
Status:Published
Refereed:Yes
Uncontrolled Keywords:RNA helicases, positive sense single-stranded RNA (ssRNA+) viruses
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Hindawi Publishing Corporation
eISSN:2090-2077
Copyright Holders:© 2011 Irene Briguglio et al.
Deposited On:28 Jan 2011 10:12

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