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Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors

Federico, Mario and Bagella, Luigi Marco (2011) Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors. Journal of Biomedicine and Biotechnology, Vol. 2011 , p. 1-12. eISSN 1110-7251. Article.

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DOI: 10.1155/2011/475641

Abstract

The human genome is epigenetically organized through a series of modifications to the histone proteins that interact with the DNA. In cancer, many of the proteins that regulate these modifications can be altered in both function and expression. One example of this is the family of histone deacetylases (HDACs), which as their name implies remove acetyl groups from the histone proteins, allowing for more condensed nucleosomal structure. HDACs have increased expression in cancer and are also believed to promote carcinogenesis through the acetylation and interaction with key transcriptional regulators. Given this, small molecule histone deacetylases inhibitors have been identified and developed, which not only inhibit HDACs, but can also lead to growth arrest, differentiation, and/or apoptosis in tumors both in vitro and in vivo. Here, we will discuss some of the recent developments in clinical trials utilizing HDACs inhibitors for the treatment of both hematological malignancies as well as solid tumors.

Item Type:Article
ID Code:5383
Status:Published
Refereed:Yes
Uncontrolled Keywords:Histone deacetylase (HDAC)inhibitors, anticancer agents, hematological malignancies, solid tumors
Subjects:Area 05 - Scienze biologiche > BIO/10 Biochimica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Hindawi Publishing Corporation
eISSN:1110-7251
Copyright Holders:© 2011 Mario Federico and Luigi Bagella
Deposited On:28 Jan 2011 10:59

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