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T-cell traffic jam in Hodgkin's lymphoma: pathogenetic and therapeutic implications

Fozza, Claudio and Longinotti, Maurizio Roberto (2011) T-cell traffic jam in Hodgkin's lymphoma: pathogenetic and therapeutic implications. Advances in Hematology, Vol. 2011 , p. 1-8. eISSN 1687-9112. Article.

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DOI: 10.1155/2011/501659


In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarized towards a memory T-helper type 2 phenotype. In this paper we will first evaluate the main processes modulating T-cell recruitment towards the lymph node microenvironment in HL, especially focusing on the role played by cytokines. We will then consider the most relevant mechanisms of immune escape exerted by neoplastic cells in order to evade antitumor immunity. The potential pathogenetic and prognostic impact of regulatory T cells in such a context will be also described. We will finally overview some of the strategies of cellular immunotherapy applied in patients with HL.

Item Type:Article
ID Code:5381
Uncontrolled Keywords:Hodgkin's lymphoma (HL) microenvironment, cytokine production, cellular immunotherapy
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
Publisher:Hindawi Publishing Corporation
Copyright Holders:© 2011 C. Fozza and M. Longinotti
Deposited On:28 Jan 2011 10:01

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