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2(3)-Aryl-thio(oxy)-methylquinoxaline derivatives: a new class of P-glycoprotein-mediated drug efflux inhibitors

Carta, Antonio and Piras, Sandra and Paglietti, Giuseppe and Pricl, Sabrina and La Colla, Paolo and Busonera, Bernardetta and Loddo, Roberta (2008) 2(3)-Aryl-thio(oxy)-methylquinoxaline derivatives: a new class of P-glycoprotein-mediated drug efflux inhibitors. Medicinal Chemistry, Vol. 4 (3), p. 194-205. ISSN 1573-4064. Article.

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DOI: 10.2174/157340608784325197

Abstract

A series of quinoxalines variously substituted, namely 3-arylthiomethyl-1,6-dimethylquinoxalin-2-ones (6a-f), 3-arylthiomethyl-1-benzyl-7-trifluoromethylquinoxalin-2-ones (8a-g) and 2-arylthiomethyl-3-benzyloxy-6-trifluoromethylquinoxalines (10a,b,e-h), were synthesized and compared with previous arylphenoxymethylquinoxalines (1a-f, 2af and 3a-b). The purpose was to verify whether the replacement of oxygen with sulphur atom and the insertion of different substituents on the phenyl side chain were able to improve the capability to inhibit the Pgp pump and restore the antiproliferative activity of clinically useful drugs, such as doxorubicin (Doxo), vincristine (VCR) and etoposide (VP16), in drugresistant human nasopharyngeal carcinoma KB cells (KBwt, KBMDR, KB7D and KBV20C). Furthermore, 2,3-bis(aryloxymethyl)- 6-trifluoromethylquinoxalines (13a-c) were designed with the objective to evaluate the capability of the double side chain to potentiate the antiproliferative activity of the drugs tested. Biological assays showed that title compounds were, in general, endowed with good activity as Pgp inhibitors. In particular compound 3a, bearing 2-CONHPh substituent on phenoxymethyl side chain, resulted the most effective, while the double side chain (compound 13c) gives the ability to inhibit a different MRP pump (a membrane glycoprotein named mrp). Furthermore, we can conclude that replacement of oxygen with sulphur atom did not improve the biological activity.

Item Type:Article
ID Code:538
Status:Published
Refereed:Yes
Uncontrolled Keywords:2(3)-aryl-thio(oxy)-methylquinoxalines, antiproliferative activity, multidrug resistance, P-glycoprotein inhibitors, MRP pump, doxorubicin, vincristine, etoposide
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Bentham Science
ISSN:1573-4064
Deposited On:18 Aug 2009 10:02

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