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PrPSc deposition in mammary gland of sheep experimentally coinfected with scrapie and Maedi-Visna virus

Cancedda, Giovanna Maria and Sigurdson, J. Chistina and Saba, Mariangela and Carcassola, Gabriella and Demontis, Franca and Uras, Patrizia and Zucca, Rosalba and Santucciu, Cinzia and Demurtas, Giulia and Maestrale, Caterina and Madau, Laura and Ligios, Ciriaco and Aguzzi, Adriano (2006) PrPSc deposition in mammary gland of sheep experimentally coinfected with scrapie and Maedi-Visna virus. In: 3. Congresso nazionale A.I.P.Vet.: atti, 11-13 Maggio 2006, Pisa, Italia. Milano, AIPVet. p. 28. ISSN 1825-2265. Conference or Workshop Item.

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Abstract

Scrapie, a fatal neurodegenerative disorder of sheep, is characterized by deposition of an abnormal isoform of prion protein (PrPSc) in the central nervous system (CNS) and within the lymphoreticular system (LRS). Recent studies in mice transgenically engineered to develop organ specific inflammation demonstrated the cooccurrence of PrPSc in the inflamed organs (kidney, pancreas and liver).

Item Type:Conference or Workshop Item (Lecture)
ID Code:535
Status:Published
Uncontrolled Keywords:Scrapie, sheep, Maedi-Visna virus, inflammation
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Istituto zooprofilattico sperimentale della Sardegna, Sassari
002 Altri enti e centri di ricerca del Nord Sardegna > Istituto zootecnico e caseario per la Sardegna, Olmedo
Publisher:AIPVet
ISSN:1825-2265
Deposited On:18 Aug 2009 10:02

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