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A Study on the role of nitric oxide and iron in 3-morpholino-sydnonimine-induced increases in dopamine release in the striatum of freely moving rats

Serra, Pier Andrea and Rocchitta, Gaia Giovanna Maria and Esposito, Giovanni and Delogu, Maria Rosaria and Migheli, Rossana and Miele, Egidio and Desole, Maria Speranza and Miele, Maddalena (2001) A Study on the role of nitric oxide and iron in 3-morpholino-sydnonimine-induced increases in dopamine release in the striatum of freely moving rats. British Journal of Pharmacology, Vol. 134 (2), p. 275-282. eISSN 1476-5381. Article.

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DOI: 10.1038/sj.bjp.0704232

Abstract

We showed previously that interaction between NO and iron (II), both released following the decomposition of sodium nitroprusside (SNP), accounted for the late SNP-induced dopamine (DA) increase in dialysates from the striatum of freely moving rats; in addition, we showed that co-infusion of iron (II) with the NO-donor S-nitroso-N-acetylpenicillamine mimicked SNP effects on striatal DA release.
In the present study, intrastriatal co-infusion of iron (II) (given as FeSO4, 1 mM for 40 min) with the NO-donor and potential peroxynitrite generator 3-morpholinosydnonimine (SIN-1) (0.2, 0.5, 1.0 or 5.0 mM for 180 min), potentiated the SIN-1-induced increase in DA concentration in dialysates from the striatum of freely moving rats. Neither alone nor associated with iron (II) did SIN-1 induce changes in dialysate ascorbic acid or uric acid concentrations.
Neither co-infusion of a superoxide dismutase mimetic nor uric acid affected SIN-1-induced increases in dialysate DA concentration.
Infusion of the iron chelator deferoxamine (0.2 mM for 180 min) decreased dialysate DA and attenuated SIN-1-induced increases in dialysate DA concentrations.
These results suggest that iron plays a key role in SIN-1-induced release of striatal DA and do not support any role for either peroxynitrite or superoxide anion in SIN-1-induced release of striatal DA.

Item Type:Article
ID Code:5338
Status:Published
Refereed:Yes
Uncontrolled Keywords:NO-donor, dopamine, in vivo release, iron, peroxynitrite, microdialysis, rat striatum
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
Publisher:Macmillan
eISSN:1476-5381
Deposited On:21 Jan 2011 17:24

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