Sotgiu, Stefano and Piana, Andrea Fausto and Pugliatti, Maura and Sotgiu, Maria Alessandra and Deiana, Giovanni Andrea and Sgaramella, Enrico and Muresu, Elena and Rosati, Giulio (2001) Chlamydia pneumoniaein the cerebrospinal fluid of patients with multiple sclerosis and neurological controls. Multiple Sclerosis Journal, Vol. 7 (6), p. 371-374. eISSN 1477-0970. Article.
Full text not available from this repository.
Chlamydia pneumoniae infection is a common event in neurological patients and recovery of C. pneumoniae DNA in the cerebrospinal fluids (CSF) of multiple sclerosis (MS) patients could represent an epiphenomenon. We assessed the relevance of C. pneumoniae infection in 62 CSF samples from 32 MS patients and 30 neurological controls by means of PCR, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. Multiple sclerosis (9.3%) and neurological controls (13.3) had similar percentage of anti-C. pneumoniae antibodies. However, C. pneumoniae DNA was only detectable in MS patients' CSF (9.3%). Our data support the hypothesis that C. pneumoniae persistence in some MS patients may be the result of an impaired clearance within the central nervous system.
I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore
Repository Staff Only: item control page