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Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls

Sotgiu, Stefano and Piana, Andrea Fausto and Pugliatti, Maura and Sotgiu, Maria Alessandra and Deiana, Giovanni Andrea and Sgaramella, Enrico and Muresu, Elena and Rosati, Giulio (2001) Chlamydia pneumoniaein the cerebrospinal fluid of patients with multiple sclerosis and neurological controls. Multiple Sclerosis Journal, Vol. 7 (6), p. 371-374. eISSN 1477-0970. Article.

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DOI: 10.1177/135245850100700605


Chlamydia pneumoniae infection is a common event in neurological patients and recovery of C. pneumoniae DNA in the cerebrospinal fluids (CSF) of multiple sclerosis (MS) patients could represent an epiphenomenon. We assessed the relevance of C. pneumoniae infection in 62 CSF samples from 32 MS patients and 30 neurological controls by means of PCR, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. Multiple sclerosis (9.3%) and neurological controls (13.3) had similar percentage of anti-C. pneumoniae antibodies. However, C. pneumoniae DNA was only detectable in MS patients' CSF (9.3%). Our data support the hypothesis that C. pneumoniae persistence in some MS patients may be the result of an impaired clearance within the central nervous system.

Item Type:Article
ID Code:5336
Uncontrolled Keywords:Chlamydia pneumoniae, cerebrospinal fluid, multiple sclerosis, polymerase chain reaction
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 06 - Scienze mediche > MED/05 Patologia clinica
Area 06 - Scienze mediche > MED/27 Neurochirurgia
Area 05 - Scienze biologiche > BIO/16 Anatomia umana
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
001 Università di Sassari > 03 Istituti > Clinica neurochirurgica
001 Università di Sassari > 03 Istituti > Igiene e medicina preventiva
Publisher:SAGE Publications
Deposited On:21 Jan 2011 16:13

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