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Hyaline bodies in Kaposi's sarcoma: an immunocytochemical and ultrastructural study

Massarelli, Giovannino and Scott, Cheryl A. and Mura, Antonica and Tanda, Francesco and Cossu, Antonio (1989) Hyaline bodies in Kaposi's sarcoma: an immunocytochemical and ultrastructural study. Applied Pathology, Vol. 7 (1), p. 26-33. ISSN 0252-1172. Article.

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The nature of hyaline bodies (HB) in Kaposi's sarcoma (KS) has been investigated by electron microscopy (EM) and immunohistochemical methods. Paraffin sections from 45 cases of KS selected on the basis of their high content of HB were challenged with antisera against factor VIIIR:Ag, carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), alpha 1-antitrypsin (A1AT), fibrinogen, hemoglobin, alpha-actin and lysozyme. HB showed positivity for all the antibodies except for the last two. By EM, HB showed features consistent with red blood cell, fibrin and platelet phagocytosis. Therefore, HB in KS are considered to be the expression of an indiscriminate process of phagocytosis which involves not only erythrocytes and platelets, but also other substances such as fibrinogen, factor VIIIR:Ag, A1AT, CEA and AFP.

Item Type:Article
ID Code:5329
Uncontrolled Keywords:Hyaline bodies (HB), Kaposi's sarcoma (KS), immunocytochemical and ultrastructural study
Subjects:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Divisions:001 Università di Sassari > 03 Istituti > Anatomia patologica
Deposited On:21 Jan 2011 13:01

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