Leoncini, Lorenzo and Lazzi, Stefano and Scano, Donatella and Mura, Antonica and Onida, Angela and Massarelli, Giovannino and Tosi, Piero and Barbini, Paolo and Cevenini, Gabriele and Massai, Maria Rita and Pileri, Stefano and Falini, Brunangelo and Giordano, Antonio and Kraft, Rainer and Laissue, Jean Albert and Cottier, Hans (2000) Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity. International Journal of Cancer, Vol. 86 (6), p. 777-781. eISSN 1097-0215. Article.
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A variable fraction of anaplastic large-cell lymphomas (ALCLs) exhibits a t(2;5)(p23;q35) translocation that results in expression of the chimeric hyperphosphorylated protein NPM-ALK (p80). Tumor cells expressing NPM-ALK exhibit markedly enhanced proliferative activity, but comparative cellular kinetic studies on ALK+ (ALK lymphomas) and ALK– lymphomas are lacking. The present study showed that ALK+ lymphomas, detected with the monoclonal antibody ALKc (n = 17), had significantly higher average values for the proliferation-associated parameters mitotic index, ana/telophase index, growth index (x × mitotic index – apoptotic index, assuming x = 3), percentages of Ki-67+ cells and fraction of cells expressing cyclin A or B or the cell cycle–regulatory protein p34cdc2 than did ALK– ALCLs (n = 15). Whether this intense proliferative activity contributes to the good response to chemotherapy and favorable outcome of ALK+ ALCLs remains to be assessed in a larger series of patients. Our findings support the notion that ALK+ and ALK– ALCLs are 2 distinct disease entities.
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