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Vanadium uptake by yeasts

Zoroddu, Maria Antonietta (1999) Vanadium uptake by yeasts. Annals of the New York Academy of Sciences, Vol. 879 (1), p. 288-291. eISSN 1749-6632. Article.

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DOI: 10.1111/j.1749-6632.1999.tb10434.x


Saccharomyces cerevisiae cells reduce vanadate V(V) to vanadyl V(IV) as a detoxification mechanism. Cells resume growth as V(V) concentration in the medium decreases as a consequence of its reduction to V(IV); the final number of cells is proportional to initial vanadate concentrations. The results of vanadyl production experiments demonstrate that vanadate reduction occurred during the exponential phase of growth. EPR spectroscopy was used to determine the concentration of vanadyl and its speciation inside the cells and in the supernatants. Toxicology of vanadium has become an area of great interest because of the increasing amounts of vanadium in the environment as a result of its use in industrial processes. The study of the essentiality and toxicology of vanadium is currently an area of great interest. The mechanisms for both toxic and beneficial effects are not well understood. When vanadium compounds in the (IV) or (V) oxidation states are given to animals, the vanadium is found in the vanadyl VO2+ form.1,3 In order to understand how inorganic processes can be involved in cellular regulation, we have been studying the alteration of metabolism caused by different concentrations of vanadium in the vanadate form. It is known that Saccharomyces cerevisiae reduces V(V) to V(IV)4–8; here, we report that the detoxification mechanism is related to this reduction and that cells can gain energy for growth by this reduction.

Item Type:Article
ID Code:5308
Uncontrolled Keywords:Saccharomyces cerevisiae, vanadate concentrations, yeast
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Blackwell / Wiley
Deposited On:12 Jan 2011 10:23

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