Cangül, Hakan and Broday, Limor and Salnikow, Konstantin and Sutherland, Jessica E. and Peng, Wu and Zhang, Qunwei and Poltaratsky, V. and Yee, Herman and Zoroddu, Maria Antonietta and Costa, Max (2002) Molecular mechanisms of nickel carcinogenesis. Toxicology Letters, Vol. 127 (1-3), p. 69-75. ISSN 0378-4274. Article.
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Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed.
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