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Molecular mechanisms of nickel carcinogenesis

Cangül, Hakan and Broday, Limor and Salnikow, Konstantin and Sutherland, Jessica E. and Peng, Wu and Zhang, Qunwei and Poltaratsky, V. and Yee, Herman and Zoroddu, Maria Antonietta and Costa, Max (2002) Molecular mechanisms of nickel carcinogenesis. Toxicology Letters, Vol. 127 (1-3), p. 69-75. ISSN 0378-4274. Article.

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DOI: 10.1016/S0378-4274(01)00485-4

Abstract

Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed.

Item Type:Article
ID Code:5303
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chromosome damage, heterochromatin, gene silencing, nickel
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:Elsevier
ISSN:0378-4274
Copyright Holders:© 2002 Elsevier Science Ireland
Deposited On:10 Jan 2011 18:50

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